Most genetic alterations linked to disease aren’t in genes but are in the ‘dark genome’. Nucleome is using new technology to shine a light in these unknown depths and find the hidden genetic connections to disease.
All tagged genomics
Larry Moran: What’s in your genome?
If less than two per cent of your genome is actual genes, then what’s the rest? Is it just junk?
Cordelia Langford: The stories behind the sequencing
Cordelia Langford is the Director of Scientific Operations at the Wellcome Sanger Institute. Her career has spanned the early days of DNA sequencing to the Human Genome Project and today’s industrial-scale genomic pipelines.
Lucy van Dorp: Tracking SARS-CoV-2 around the world, from animals to humans and back again
At the beginning of 2020, UCL group leader Lucy van Dorp set to work using her genetic analysis skills to track the SARS-CoV-2 virus as it spread and mutated in animals as well as humans, providing vital insights to help us understand and tackle the pandemic.
Natalie Frankish: From a Diagnostic Odyssey to a Good Diagnosis
Natalie Frankish from Genetic Alliance UK explains the long route to diagnosis for patients with rare genetic diseases and what a good diagnosis should look like.
Dr Joe Marsh: Understanding the role of Variants of Unknown Significance in rare disease
Dr Joe Marsh at the MR Human Genetics Unit is trying to figure out how variations in the genome might cause disease.
Krystal Tsosie: Exploring Native American genetics
Krystal Tsosie joins us to discuss why Native American genomes are of such interest to modern geneticists, and how Indigenous researchers are working to take ownership of the field.
Genes Down Under
A new platypus genome helps to explain some of the unusual characteristics of this mysterious monotreme
Sara Hull: Responsible genomics research with tribal and indigenous communities
Sara Hull is a bioethicist at the National Institutes of Health who helps genomics researchers make sure their work is done ethically and doesn’t cause harm to the people involved.
Charles Rotimi: Powering up African genetics research
Charles Rotimi is the driving force behind the Human Heredity and Health in Africa (H3Africa) project looking at genomics and health across the continent.
Steve Rees: Homing in on the right targets
Steve Rees and his team at AstraZeneca are focusing on the first step of the drug discovery journey: coming up with the new ideas and targets that could lead to the new medicines of tomorrow.
Dave Michalovich: Using AI to seek out new drug targets
Dave Michalovich from Benevolent AI discusses how artificial intelligence (AI) and machine learning can help researchers figure out what might be going on in disease and home in on the best targets for new therapies.
David Goldstein: Mining the genome for medical insights
David Goldstein from Columbia University Medical Center explains how to turn the complex information within the human genome into insights that can lead to better medicines for patients.
Searching for genetic superheroes
The search for genetic superheroes started with a simple question with a complicated answer: not why do we get sick, but why do we stay well?
Ringo the Superdog: how rare genetic variations can lead to new treatments
How a super-powered pup is paving the way for new treatments for muscular dystrophy.